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Stephen Provencher Inc lcmodel software
Lcmodel Software, supplied by Stephen Provencher Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/lcmodel+software/lcmodel+software/pm42029746-81-5-7
Average 86 stars, based on 1 article reviews
lcmodel software - by Bioz Stars, 2026-09
86/100 stars

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Article Title: Proton magnetic resonance spectroscopy for the prediction to drug responsiveness of mesial temporal lobe epilepsy according to ILAE definition.
Article Snippet: Objective: Approximately 30-40% of patients with mesial temporal lobe epilepsy (MTLE) develop drug resistance, yet conventional MRI measures lack sufficient accuracy for early identification of drug-resistant cases.. Proton magnetic resonance spectroscopy (1H-MRS), as a non-invasive technique, enables quantitative assessment of neurometabolic alterations in epileptogenic regions.. We hypothesized 1H MRS may assist in distinguish ASM responsiveness of newly diagnosed MTLE patients and aimed to establish clinically neuroimage actionable biomarkers.

Article Title: In Vivo Assessment of Astrocyte Reactivity in Patients with Progressive Supranuclear Palsy.
Article Snippet: .. A weighted combination of receiver channels was performed using the FID-A toolkit, followed by removal of motion-corrupted averages, spectral registration for frequency and phase drift correction, and alignment of subspectra prior to subtraction.21 MRS data were processed using LCModel software (Stephen Provencher, Oakville, Canada) for a linear combination of model spectra with simulated basis functions.22 We used a neurochemical basis set that incorporated 9 macromolecular basis functions, each sourced from the individual peaks in a macromolecular spectrum obtained by the summation of experimentally acquired metabolite-nulled spectra from 6 healthy adult volunteers. ..

Article Title: In vivo assessment of astrocyte reactivity in patients with progressive supranuclear palsy
Article Snippet: .. MRS data were processed using LCModel software (Stephen Provencher, Inc.) for a linear combination of model spectra with simulated basis functions. ..

Article Title: Interactions of catecholamines and GABA+ in cognitive control: Insights from EEG and 1 H-MRS.
Article Snippet: .. After exporting the data (“edit on”, “edit off”, svs_se30_ in *.rda format) directly from the spectroscopy subroutine of the scanner, difference spectra were calculated (using an inhouse python script) and loaded into LCModel software (v6.3–1H, copyright Stephen Provencher, Canada). .. Basis sets for MEGA-PRESS were delivered by Ulrike Dydak`s Lab at Purdue University (https://www.purdue.edu/hhs/hsci/mrs lab/basis_sets.html).

Article Title: Altered Brain Energy Metabolism Related to Astrocytes in Alzheimer's Disease.
Article Snippet: .. MRS data were analyzed using LCModel software (Stephen Provencher, Oakville, ON, Canada) for a linear combination of model spectra with simulated basis functions.27 The neurochemical basis set used included 9 macromolecular basis functions, each derived from the individual peaks in a macromolecular spectrum that was obtained by summing experimentally acquired metabolite-nulled spectra from 6 healthy adult volunteers. ..

Article Title: Altered astrocyte-neuron crosstalk in progressive supranuclear palsy: integrated evidence from proteomics and magnetic resonance spectroscopy.
Article Snippet: The anterior cingulate cortex (ACC), crucial for executive function, is frequently impaired in progressive supranuclear palsy (PSP), yet mechanisms underlying this selective vulnerability remain unclear.. Given the integration of astrocytes into neural circuits, we hypothesized that astrocyte dysfunction and altered astrocyte–neuron crosstalk contribute to functional abnormalities in the ACC in PSP.. To test this hypothesis, we conducted a multimodal analysis integrating SWATH-MS-based proteomics, histopathology, and in vivo magnetic resonance spectroscopy (MRS) in postmortem and living brains of patients with PSP and healthy controls (HCs).

Article Title: Investigating neural dysfunction with abnormal protein deposition in Alzheimer’s disease through magnetic resonance spectroscopic imaging, plasma biomarkers, and positron emission tomography
Article Snippet: .. We analyzed MRSI data using LCModel software (Stephen Provencher, Inc) ( ) for a linear combination of model spectra provided in a basis set. ..

Article Title: Investigating neural dysfunction with abnormal protein deposition in Alzheimer's disease through magnetic resonance spectroscopic imaging, plasma biomarkers, and positron emission tomography.
Article Snippet: .. We analyzed MRSI data using LCModel software (Stephen Provencher, Inc) (Provencher, 1993) for a linear combination of model spectra provided in a basis set. ..

Spectroscopy:

Article Title: Interactions of catecholamines and GABA+ in cognitive control: Insights from EEG and 1 H-MRS.
Article Snippet: .. After exporting the data (“edit on”, “edit off”, svs_se30_ in *.rda format) directly from the spectroscopy subroutine of the scanner, difference spectra were calculated (using an inhouse python script) and loaded into LCModel software (v6.3–1H, copyright Stephen Provencher, Canada). .. Basis sets for MEGA-PRESS were delivered by Ulrike Dydak`s Lab at Purdue University (https://www.purdue.edu/hhs/hsci/mrs lab/basis_sets.html).

Derivative Assay:

Article Title: Altered Brain Energy Metabolism Related to Astrocytes in Alzheimer's Disease.
Article Snippet: .. MRS data were analyzed using LCModel software (Stephen Provencher, Oakville, ON, Canada) for a linear combination of model spectra with simulated basis functions.27 The neurochemical basis set used included 9 macromolecular basis functions, each derived from the individual peaks in a macromolecular spectrum that was obtained by summing experimentally acquired metabolite-nulled spectra from 6 healthy adult volunteers. ..



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